604734: Allergen Profile, Hazelnut, IgE With Component Reflexes (2024)

1. Blanc F, Bernard H, Ah-Leung S, et al. Further studies on the biological activity of hazelnut allergens. Clin Transl Allergy. 2015 Jul 17; 5:26. 26191402

2. Chokshi NY, Sicherer SH. Interpreting IgE sensitization tests in food allergy. Expert Rev Clin Immunol. 2015 Dec; 1-15. 26666347

3.Canonica GW, Ansotegui IJ, Pawankar R, et al. A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J. 2013 Oct 3; 6(1):17. 24090398

4. Incorvaia C, Rapetti A, Aliani M, et al. Food allergy as defined by component resolved diagnosis. Recent Pat Inflamm Allergy Drug Discov. 2014 Jan; 8(1):59-73. 24483212

5. Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update−2014. J Allergy Clin Immunol. 2014 Nov; 134(5):1016-1025. 25174862

6. Kattan JD, Sicherer SH. Optimizing the diagnosis of food allergy. Immunol Allergy Clin North Am. 2015 Feb; 35(1):61-76. 25459577

7. Pastorello EA, Vieths S, Pravettoni V, et al. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol. 2002 Mar; 109(3):563-570. 11898007

8. Flinterman AE, Hoekstra MO, Meijer Y, et al. Clinical reactivity to hazelnut in children: association with sensitization to birch pollen or nuts? J Allergy Clin Immunol. 2006 Nov; 118(5):1186-1189. 17088148

9. Flinterman AE, Akkerdaas JH, Knulst AC, van Ree R, Pasmans SG. Hazelnut allergy: From pollen-associated mild allergy to severe anaphylactic reactions. Curr Opin Allergy Clin Immunol. 2008 Jun; 8(3):261-265. 18560303

10. Sicherer SH, Muñoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010; 125(6):1322-1326. 20462634

11. De Knop KJ, Verweij MM, Grimmelikhuijsen M, et al. Age-related sensitization profiles for hazelnut (Corylus avellana) in a birch-endemic region. Pediatr Allergy Immunol. 2011 Feb; 22(1Pt 2):e139-149. 21342279

12. Masthoff LJ, van Hoffen E, de Reus A, et al. Hazelnut allergy differs between children and adults in frequency of severity, aetiology and relevance of diagnostic parameters. Clin Exp Allergy. 2014 Dec; 44(12):1539-1545. 25333730

13. Flinterman AE, Akkerdaas JH, den Hartog Jager CF, et al. Lipid transfer protein-linked hazelnut allergy in children from a non-Mediterranean birch-endemic area. J Allergy Clin Immunol. 2008 Feb; 121(2):423-428. 18036652

14. Faber MA, De Graag M, Van Der Heijden C, et al. Cor a 14: Missing link in the molecular diagnosis of hazelnut allergy? Int Arch Allergy Immunol. 2014; 164(3):200-206. 25034302

15. Garino C, Zuidmeer L, Marsh J, et al. Isolation, cloning, and characterization of the 2S albumin: a new allergen from hazelnut. Mol Nutr Food Res. 2010 Sep; 54(9):1257-1265. 20373288

16. Verweij MM, Hagendorens MM, De Knop KJ, et al. Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin-like seed-storage protein from hazelnut (Corylus avellana). Pediatr Allergy Immunol. 2011 Mar; 22(2):196-201. 20579306

17. Eller E, Mortz CG, Bindslev-Jensen C. Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy. Allergy. 2015 Dec 15. doi: 10,11/all.12820. 26666993

18. Beyer K, Grabenhenrich L, Härtl M, et al. Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children. Allergy. 2015 Jan; 70(1):90-98. 25308885

19. Kattan JD, Sicherer SH, Sampson HA. Clinical reactivity to hazelnut may be better identified by component testing than traditional testing methods. J Allergy Clin Immunol Pract. 2014. 2(5): p. 633-634 e1.

20. Masthoff LJ, Mattsson L, Zuidmeer-Jongejan L, et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a severe hazelnut allergy in Dutch children and adults. J Allergy Clin Immunol. 2013 Aug; 132(2):393-399. 23582909

21. Carraro S, Berardi M, Bozzetto S, Baraldi E, Zanconato S. COR a 14-specific IgE predicts symptomatic hazelnut allergy in children. Pediatr Allergy Immunol. 2015 Dec 17. doi: 10,11/pai.12526. 26680531

22. Datema MR, Zuidmeer-Jongejan L, Asero R, et al. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J Allergy Clin Immunol. 2015 Aug; 136(2):382-391. 25772593

23. Asero R, Mistrello G, Roncarolo D, Amato S. Walnut-induced anaphylaxis with cross-reactivity to hazelnut and Brazil nut. J Allergy Clin Immunol. 2004 Feb; 113(2):358-360. 14767457

24. Ebo DG, Verweij MM, Sabato V, Hagendorens MM, Bridts CH, De Clerck LS. Hazelnut allergy: A multi-faced condition with demographic and geographic characteristics. Acta Clin Belg. 2012 Sep-Oct; 67(5):317-321. 23189537

25. Uotila R, Kukkonen AK, Pelkonen A, Mäkelä MJ. Cross-sensitization profiles of edible nuts in a birch-endemic area. Allergy. 2015 Dec 25. doi: 10,11/all. 12826. 26706253

26. Hansen KS, Ballmer-Weber BK, Lüttkopf D, et al. Roasted hazelnuts—allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy. 2003 Feb; 58(2):132-138. 12622744

27. Werfel T, Asero R, Ballmer-Weber BK, et al. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy. 2015 Sep; 70(9):1079-1090. 26095197

28. Egger M, Hauser M, Mari A, Ferreira F, Gadermaier G. The role of lipid transfer proteins in allergic diseases. Curr Allergy Asthma Rep. 2010 Sep; 10(5):326-335. 20582490

29. Hartz C, Lauer I, del Mar San Miguel Moncin M, et al. Comparison of IgE-binding capacity, cross-reactivity and biological potency of allergenic non-specific lipidtransfer proteins from peach, cherry and hazelnut. Int Arch Allergy Immunol. 2010; 153(4):335-346. 20558999

30. Schulten V, Nagl B, Scala E, et al. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its hom*olog in hazelnut. Allergy. 2011 Aug; 66(8):1005-1013. 21352239

31. Schocker F, Lüttkopf D, Scheurer S, et al. Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in vitro diagnosis of potentially severe hazelnut allergy. J Allergy Clin Immunol. 2004 Jan; 113(1):141-147. 14713920

32. Hansen KS, Ballmer-Weber BK, Sastre J, et al. Component-resolved in vitro diagnosis of hazelnut allergy in Europe. J Allergy Clin Immunol. 2009 May; 123(5):1134-1141. 19344939

33. Verweij MM, Hagendorens MM, Trashin S, et al. Age-dependent sensitization to the 7S-vicilin-like protein Cor a 11 from hazelnut (Corylus avellana) in a birch-endemic region. J Investig Allergol Clin Immunol. 2012; 22(4):245-251. 22812192

FAQs

What are the IgE levels for hazelnut allergy? ›

Total Hazelnut IgE and Hazelnut Components Ranges: kUA/L: Interpretation: <0.1 *Absent 0.1 – 0.34 Equivocal/Low 0.35 – 0.69 Low 0.70 – 3.49 Medium 3.50 – 17.49 High 17.50 – 49.99 Very High 50.00 – 100.00 Very High >100.00 Very High *If Total Hazelnut is <0.1 kUA/L, Hazelnut component testing is not indicated.

Is a hazelnut allergy serious? ›

Allergies to tree nuts such as hazelnuts are common and often severe. These types of allergies typically develop by the age of 2, and the number of tree nuts to which a person is allergic may increase with age. Roughly 30 percent of people with a tree nut allergy are allergic to more than one nut.

Learn More ›

What foods should you avoid if you have a hazelnut allergy? ›

If you have a hazelnut allergy, avoid hazelnuts and any product containing them. This includes Nutella, certain chocolates, pralines, and baked goods. Also, be wary of hazelnut oil in cooking and cosmetic products. Always check labels for potential cross-contamination in food manufacturing.

Keep Reading ›

What is a high IgE level for allergies? ›

An elevated IgE level (100 ≥ IgE < 1000 kU/L) indicates allergy, eczema, or chronic skin infection.

Learn More ›

What is a normal allergen range? ›

Reference Interval

Age	Reference Interval (kU/L)
9-12 years	696 or less
13-15 years	629 or less
16-17 years	537 or less
18 years and older	214 or less

6 more rows

Explore More ›

What if the IgE level is more than 1000? ›

At the same time, the normal range of IgE levels for adults falls within the range of 150 to 1000 IU/ml. The IgE levels above the normal range can suggest various health issues such as asthma, hay fever, or eczema. In some cases, extremely high IgE levels can cause certain rare immunodeficiency disorders.

Learn More ›

What is the normal range of IgE level? ›

The serum IgE test normal range can range from 150 to 1,000 UI/ml, but the commonly accepted maximum limit is between 150 and 300 UI/ml.

Keep Reading ›

What is the highest number on an allergy test? ›

You will receive IgE test results for the allergen being tested as a number ranging from 0.10 to, in some cases, above 100. If there is no detectable level of IgE, then you are not sensitized to that allergen.

Find Out More ›

What is the rarest allergy to get? ›

The Rarest (And Strangest) Allergies

Water: Medically known as aquagenic urticaria, patients with a water allergy develop painful hives and rashes when their skin is exposed to water. An allergic reaction will develop regardless of the water temperature, and even when the water is purified.

Keep Reading ›

Who should avoid hazelnut? ›

Allergic Diseases: Hazelnut allergy is associated with other allergic diseases, such as food allergies, asthma, atopic dermatitis, and allergic rhinitis. Cross-Reactivity: People with an allergy to other tree nuts, fruits, soybeans, vegetables, and legumes may also have a hazelnut allergy due to cross-reactivity.

Learn More ›

What are the major allergens in hazelnut? ›

Background: The hazelnut major allergens identified to date are an 18-kd protein hom*ologous to Bet v 1 and a 14-kd allergen hom*ologous to Bet v 2.

Class	IgE kU/L	Interpretation
1	0.35-0.69	Equivocal
2	0.70-3.49	Positive
3	3.50-17.4	Positive
4	17.5-49.9	Strongly positive